2 edition of Effect of sodium polystyrene sulfonate on lithium bioavailability found in the catalog.
Effect of sodium polystyrene sulfonate on lithium bioavailability
Denis R. Belanger
|Contributions||Tierney, Michael G., Dickinson, Garth E., Ottawa General Hospital.|
|The Physical Object|
|Number of Pages||27|
Polystyrene sulfonates are useful because of their ion exchange properties. Water softening. Water softening is achieved by percolating hard water through a bed of the sodium form of cross-linked polystyrene sulfonate. The hard ions such as calcium (Ca 2+) and magnesium (Mg 2+) adhere to the sulfonate groups, displacing sodium ions. The resulting solution of sodium ions is ncy category: US: C (Risk not ruled out). Sodium polystyrene sulfonate binds to many commonly prescribed oral medicines, decreasing the absorption and therefore the effectiveness of those oral medicines. Commercially Available Suspension Shake the suspension well before administering. If necessary, sodium polystyrene sulfonate may be administered into the stomach through a plastic tube.
Effect of sodium polystyrene sulfonate on lithium bioavailability. Bélanger DR, Tierney MG, Dickinson G Ann Emerg Med, 21(11), 01 Nov Appropriate studies have not been performed on the relationship of age to the effects of sodium polystyrene sulfonate in the pediatric population. However, pediatric-specific problems that would limit the usefulness of this medicine in children are not expected.
SODIUM POLYSTYRENE SULFONATE takes potassium out of the body by binding to it in the intestines. It is used to treat too much potassium in the body. The lowest GoodRx price for the most common version of sodium polystyrene sulfonate is around $, 64% off the average retail price of $ The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately mEq (in vivo approximately 1 mEq) of potassium per gram. The sodium content is approximately mg ( mEq) per gram of the drug.
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Conclusion: Sodium polystyrene sulfonate and sorbitol may be used in patients immediately or shortly after ingestion of a significant acute overdose of lithium in situations in which hemodialysis cannot be insti- tuted promptly.
[BOlanger DR, Tierney MG, Dickinson G: Effect of sodium polystyrene sulfonate on lithium by: Effect of sodium polystyrene sulfonate on lithium bioavailability. The infants had no clinically noticeable side effects. Addition of large amounts of sodium polystyrene sulfonate to artificial formula also lowers the calcium, copper, manganese, phosphorus, sulfur and zinc concentrations; whereas the iron, sodium and sulfur content of formulas are increased. Similar changes might occur with breastmilk.
Case reportUse of sodium polystyrene sulfonate in an acute-on-chronic lithium poisoned patient: A case report.
Use of sodium polystyrene sulfonate in an acute-on-chronic lithium poisoned patient: A case report. Author links open overlay panel. Chakroun-WalhaOlfa1 KsibiHichem1 RejebImen1 Boujelben Mariem1 ChaariAdel1 ChtaraKamilia2 BouazizMounir2 Rekik : Chakroun-Walha Olfa, Ksibi Hichem, Rejeb Imen, Boujelben Mariem, Chaari Adel, Chtara Kamilia, Bouazi.
Successful treatment of lithium toxicity with sodium polystyrene sulfonate: a retrospective cohort study. Ghannoum M(1), Lavergne V, Yue CS, Ayoub P, Perreault MM, Roy L. Author information: (1)Department of Nephrology, Verdun Hospital, Verdun, QC, Canada.
[email protected] by: Context. Lithium (Li) is a first-line treatment for bipolar disorder but has a narrow therapeutic index. Treatment of Li toxicity includes supportive measures and hemodialysis in severe cases, but this modality is not always immediately available.
Sodium polystyrene sulfonate (SPS, Kayexalate™), a cation exchanger, has been promising in animal models and human reports to Cited by: The possible effects of sodium polystyrene sulfonate on serum electrolytes should be considered when inter-preting diagnostic measurements.
After use of sodium polystyre ne sulfonate retention en-emas, the colon should be irrigated to ensure removal of the resin. Interactions Sodium polystyrene sulfonate is not totally selective. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has.
Abstract. Lithium salts, particularly lithium carbonate, are widely used to treat bipolar disorders. Although most literature cites the seminal article published in by the Australian psychiatrist Cade  as the initial study promulgating the efficacy of lithium salts in the treatment of mania, many earlier publications recognized its potential utility in the treatment of mood disorders.
PubMed:Sodium polystyrene sulfonate: a cation exchange resin used in treating hyperkalemia. PubMed:Hyponatremia, hyperkalemia and hypercalcemia after ileal conduit diversion.
PubMed:Effect of sodium polystyrene sulfonate on lithium bioavailability. PubMed:Lithium absorption prevented by sodium polystyrene sulfonate in volunteers.
Removes potassium by exchanging sodium ions for potassium ions in the intestine before the resin is passed from the body; exchange capacity is 1 mEq/g in vivo, and in vitro capacity is mEq/g, therefore, a wide range of exchange capacity exists such that close monitoring of serum electrolytes is necessary.
Bélanger DR, Tierney MG, Dickinson G. Effect of sodium polystyrene sulfonate on lithium bioavailability.
Ann Emerg Med ; Linakis JG, Hull KM, Lacouture PG, et al. Sodium polystyrene sulfonate treatment for lithium toxicity: effects on serum potassium concentrations.
Acad Emerg Med ; Sodium polystyrene sulfonate may decrease the absorption of lithium (Eskalith, Lithobid). Sodium polystyrene sulfonate may decrease the absorption of thyroxine or levothyroxine. Therefore, the administration of thyroid hormones and sodium polystyrene sulfonate should. Sodium Polystyrene Sulfonate for suspension may decrease absorption of lithium.
Thyroxine Sodium Polystyrene Sulfonate for suspension may decrease absorption of thyroxine. Carcinogenesis, Mutagenesis, Impairment of Fertility Studies have not been performed.
Pregnancy Category C. Compared with control, sodium polystyrene sulfonate and sorbitol reduced the area under the lithium serum concentration-time curve by %, reduced the mean observed peak serum lithium. Sodium polystyrene sulfonate may decrease your absorption of other medications. Take your other medications as directed by your doctor, usually at least 3 hours before or 3 hours after sodium.
The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately mEq (in vivo approximately 1 mEq) of potassium per sodium content is approximately mg ( mEq) per gram of the drug/ Loop diuretics may increase serum lithium levels and potentiate the risk of lithium toxicity.
The exact mechanism is unknown but may be related to the sodium loss induced by loop diuresis, which produces a compensatory increase in proximal tubular reabsorption of sodium along with lithium.
Polystyrene sulfonates are polymers derived from polystyrene but containing sulfonic acid or sulfonate functional groups. The linear polymer is white when very pure and is water-soluble. Sodium polystyrene sulfonate treatment of lithium toxicity: Effects on serum potassium concentrations.
Academic Emergency Medicine, ; Suner S, Jagminas L, Peipert JF, Linakis JG: Fatal spontaneous rupture of a gravid uterus: Case report and literature review of uterine rupture. American. The only clinical data supporting the use of sodium polystyrene sulfonate are from one retrospective, uncontrolled analysis.
38 Sodium polystyrene sulfonate is contraindicated in patients with obstructive bowel disease. Cases of colonic necrosis have been reported and are probably related to the large dose of sorbitol associated with its use.Sodium polystyrene sulfonate comes as a suspension and as an oral powder for suspension to take by mouth.
The suspension may also be given rectally as an enema. Sodium polystyrene sulfonate is usually taken or used one to four times a day. Take or use sodium polystyrene sulfonate at around the same time(s) every day.Sodium Polystyrene Sulfonate (Oral Route) Print.
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